URL: http://interactome-cmp.ucsf.edu/
Proper Citation: Krogan Lab Interactome Database (RRID:SCR_008121)
Description: This database currently holds E-MAP scores (individual interactions and correlation coefficients) for budding yeast genes involved in the early secretory pathway and chromosome function (including DNA damage and repair, transcriptional control, chromosome segregation and telomere regulation). E-MAPs (Epistatic Mini Array Profiles) are formed by creating and quantifying high-density genetic interaction maps. With this method, observed double mutant colony sizes are compared to those that would be expected from a distribution of typical double mutant colonies of each strain. Each interaction is assigned a score, which indicates the magnitude of the difference from the expected value and the certainty of the score. Negative (or aggravating) scores (< -2.5) correspond to synthetic sick/lethal interactions while positive (or alleviating) scores (> +2.5) corresponds to epistatic or suppressor interactions.
Synonyms: Interactome
Resource Type: data or information resource, database
Keywords: function, gene, chromosome, dna, pathway, secretory, telomere regulation, transcriptional control, yeast
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